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When patients lose significant weight on incretin-based therapiesoften 10-15% or more of initial body weight in clinical trials such as the STEP program (semaglutide) and SURMOUNT trials (tirzepatide)the reduction in subcutaneous fat decreases the body's natural insulation layer, making environmental temperatures feel colder than before

For researchers publishing data or tracking precise outcomes, batch consistency is not optional

Real-world results can vary based on individual commitment and lifestyle factors

This medicine helps improve post-meal glucose regulation and overall blood sugar control when combined with a healthy diet and regular exercise

The same caution applies during pregnancy, and for a defined period before conception